Keep the index

Tuberculosis in the elderly: Keep a high index of suspicion

Elderly persons with active tuberculosis may present with the classic features, such as cough, hemoptysis, and fever, but some patients present with less typical signs, such as hepatosplenomegaly, liver function abnormalities, and anemia. A high index of suspicion is required when a patient presents with cough or pneumonia unresponsive to conventional therapy. Acid-fast smear and mycobacterial ...

The Keep Emulation Framework

As part of the overall KEEP Project the task of the Emulation Framework (EF) is to provide the emulation environments required for this purpose. In a very simple and comprehensible way the users can employ emulations for the representation and the performance of both digital objects in obsolete data formats and applications for antiquated computer systems. The virtual reconstruction of original...

Keep testing the waters.

Keep the motor running

The swirling movements of the centrosome and microtubules in a live Dictyostelium cell are shown in this sequence of images. These were taken over the course of about five minutes using α-tubulin tagged with a green fluorescent protein. The movements are more frenetic than usual because the cell is a mutant that over-expresses the motor domain of the protein dynein. Dynein has several roles in ...

Keep the celebrations short.

P atient safety seems irritatingly positive. Its scientific literature and conference proceedings are replete with tales of improvement and stories of success. This is partly understandable. It is difficult to move people and organisations to change when the outcome is uncertain; hospitals and funding organisations do not like to hear that projects in which they have invested have failed; ‘‘saf...